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Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID
Somatic hypermutation (SHM) of Ig genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene transcription. We previously proposed that AID may associate with the RNA polymerase II (Pol). Here, to determine aspects of the transcription process required for SHM, w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698518/ https://www.ncbi.nlm.nih.gov/pubmed/23752228 http://dx.doi.org/10.1084/jem.20121523 |