N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8(+) T cell memory but not to effector differentiation

Signals from the TCR that specifically contribute to effector versus memory CD8(+) T cell differentiation are poorly understood. Using mice and adoptively transferred T lymphocytes lacking the small GTPase N-ras, we found that N-ras–deficient CD8(+) T cells differentiate efficiently into antiviral p...

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Detalles Bibliográficos
Autores principales: Iborra, Salvador, Ramos, Manuel, Arana, David M., Lázaro, Silvia, Aguilar, Francisco, Santos, Eugenio, López, Daniel, Fernández-Malavé, Edgar, Del Val, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698526/
https://www.ncbi.nlm.nih.gov/pubmed/23776078
http://dx.doi.org/10.1084/jem.20112495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698526/
https://www.ncbi.nlm.nih.gov/pubmed/23776078
http://dx.doi.org/10.1084/jem.20112495

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