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N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8(+) T cell memory but not to effector differentiation
Signals from the TCR that specifically contribute to effector versus memory CD8(+) T cell differentiation are poorly understood. Using mice and adoptively transferred T lymphocytes lacking the small GTPase N-ras, we found that N-ras–deficient CD8(+) T cells differentiate efficiently into antiviral p...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698526/ https://www.ncbi.nlm.nih.gov/pubmed/23776078 http://dx.doi.org/10.1084/jem.20112495 |