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CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G
Oxidative stress is implicated in carcinogenesis, aging, and neurodegenerative diseases. The E3 ligase C terminus of Hsc-70 interacting protein (CHIP) has a protective role against various stresses by targeting damaged proteins for proteasomal degradation, and thus maintains protein quality control....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698548/ https://www.ncbi.nlm.nih.gov/pubmed/23764847 http://dx.doi.org/10.1038/cddis.2013.181 |