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Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction

Drugs that kill tuberculosis more quickly could shorten chemotherapy significantly. In Escherichia coli, a common mechanism of cell death by bactericidal antibiotics involves the generation of highly reactive hydroxyl radicals via the Fenton reaction. Here we show that vitamin C, a compound known to...

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Detalles Bibliográficos
Autores principales: Vilchèze, Catherine, Hartman, Travis, Weinrick, Brian, Jacobs, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698613/
https://www.ncbi.nlm.nih.gov/pubmed/23695675
http://dx.doi.org/10.1038/ncomms2898