Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension

BACKGROUND: Pulmonary vascular remodeling in pulmonary hypertension (PH) is characterized by increased vascular smooth muscle cell (SMC) and adventitial fibroblast proliferation, small vessel occlusion, and inflammatory cell accumulation. The underlying molecular mechanisms driving progression remai...

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Detalles Bibliográficos
Autores principales: Horita, Henrick, Furgeson, Seth B., Ostriker, Allison, Olszewski, Kyle A., Sullivan, Timothy, Villegas, Leah R., Levine, Michelle, Parr, Jane E., Cool, Carlyne D., Nemenoff, Raphael A., Weiser‐Evans, Mary C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698782/
https://www.ncbi.nlm.nih.gov/pubmed/23727701
http://dx.doi.org/10.1161/JAHA.113.000188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698782/
https://www.ncbi.nlm.nih.gov/pubmed/23727701
http://dx.doi.org/10.1161/JAHA.113.000188

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