Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors

The chimeric fusion protein, AML1-ETO, generated by translocation of t(8;21), abnormally recruits histone deacetylase (HDAC) to the promoters of AML1 target genes, resulting in transcriptional repression of the target genes and development of t(8;21) acute myeloid leukemia. Abnormal expression of cy...

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Detalles Bibliográficos
Autores principales: Zhang, Zhihua, Hao, Changlai, Wang, Lihong, Liu, Peng, Zhao, Lei, Zhu, Cuimin, Tian, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699303/
https://www.ncbi.nlm.nih.gov/pubmed/23836985
http://dx.doi.org/10.2147/OTT.S46135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699303/
https://www.ncbi.nlm.nih.gov/pubmed/23836985
http://dx.doi.org/10.2147/OTT.S46135

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