Ground State Destabilization by Anionic Nucleophiles Contributes to the Activity of Phosphoryl Transfer Enzymes

Enzymes stabilize transition states of reactions while limiting binding to ground states, as is generally required for any catalyst. Alkaline Phosphatase (AP) and other nonspecific phosphatases are some of Nature's most impressive catalysts, achieving preferential transition state over ground s...

Descripción completa

Detalles Bibliográficos
Autores principales: Andrews, Logan D., Fenn, Tim D., Herschlag, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699461/
https://www.ncbi.nlm.nih.gov/pubmed/23843744
http://dx.doi.org/10.1371/journal.pbio.1001599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699461/
https://www.ncbi.nlm.nih.gov/pubmed/23843744
http://dx.doi.org/10.1371/journal.pbio.1001599

Ejemplares similares