MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands

The inhibition of the Ras/mitogen-activated protein kinase (Ras/MAPK) pathway through the suppression of mutated Ras or MAPK/extracellular signal-regulated kinase 1/2 (MEK1/2) has been shown to sensitize tumor cells to ionizing radiation (IR). The molecular mechanisms of this sensitization however,...

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Detalles Bibliográficos
Autores principales: CHUNG, EUN JOO, URICK, MARY ELLEN, KURSHAN, NAAMIT, SHIELD, WILLIAM, ASANO, HIROAKI, SMITH, PAUL D., SCROGGINS, BRADLEY S., BURKEEN, JEFFREY, CITRIN, DEBORAH E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699614/
https://www.ncbi.nlm.nih.gov/pubmed/23588995
http://dx.doi.org/10.3892/ijo.2013.1890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699614/
https://www.ncbi.nlm.nih.gov/pubmed/23588995
http://dx.doi.org/10.3892/ijo.2013.1890

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