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Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21

Tripartite motif-containing 21 (TRIM21) is a cytosolic immunoglobulin receptor that mediates antibody-dependent intracellular neutralization (ADIN). Here we show that TRIM21 potently inhibits the spreading infection of a replicating cytopathic virus and activates innate immunity. We used a quantitat...

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Detalles Bibliográficos
Autores principales:	Watkinson, R. E., Tam, J. C. H., Vaysburd, M. J., James, L. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2013
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700317/ https://www.ncbi.nlm.nih.gov/pubmed/23596308 http://dx.doi.org/10.1128/JVI.00647-13

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