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Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography

BACKGROUND: We investigated longitudinal right ventricular (RV) function assessed using speckle-tracking strain echocardiography in patient with myocardial infarction (MI), and identified the contributing factors for RV dysfunction. METHODS: We retrospectively studied 71 patients with old MI (the OM...

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Autores principales: Konishi, Katsuhisa, Dohi, Kaoru, Tanimura, Muneyoshi, Sato, Yuichi, Watanabe, Kiyotaka, Sugiura, Emiyo, Kumagai, Naoto, Nakamori, Shiro, Nakajima, Hiroshi, Yamada, Tomomi, Onishi, Katsuya, Nakamura, Mashio, Nobori, Tsutomu, Ito, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700756/
https://www.ncbi.nlm.nih.gov/pubmed/23802850
http://dx.doi.org/10.1186/1476-7120-11-23
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author Konishi, Katsuhisa
Dohi, Kaoru
Tanimura, Muneyoshi
Sato, Yuichi
Watanabe, Kiyotaka
Sugiura, Emiyo
Kumagai, Naoto
Nakamori, Shiro
Nakajima, Hiroshi
Yamada, Tomomi
Onishi, Katsuya
Nakamura, Mashio
Nobori, Tsutomu
Ito, Masaaki
author_facet Konishi, Katsuhisa
Dohi, Kaoru
Tanimura, Muneyoshi
Sato, Yuichi
Watanabe, Kiyotaka
Sugiura, Emiyo
Kumagai, Naoto
Nakamori, Shiro
Nakajima, Hiroshi
Yamada, Tomomi
Onishi, Katsuya
Nakamura, Mashio
Nobori, Tsutomu
Ito, Masaaki
author_sort Konishi, Katsuhisa
collection PubMed
description BACKGROUND: We investigated longitudinal right ventricular (RV) function assessed using speckle-tracking strain echocardiography in patient with myocardial infarction (MI), and identified the contributing factors for RV dysfunction. METHODS: We retrospectively studied 71 patients with old MI (the OMI group) and 45 normal subjects (the Control group) who underwent a transthoracic echocardiography. Global and free wall RV peak systolic strains (PSSs) in the longitudinal direction were measured by using speckle-tracking strain echocardiography. Left ventricular (LV) PSSs were measured in the longitudinal, radial and circumferential directions. Cardiac hemodynamics including peak systolic pulmonary artery pressure was also assessed non-invasively. Plasma brain natriuretic peptide (BNP) levels were measured in all patients. RESULTS: In the OMI group, 73% of the patients had a normal estimated peak systolic pulmonary artery pressure of less than 35 mmHg. Global and free wall RV PSS were impaired in the OMI group compared with the Control group, and these RV systolic indices were significantly associated with heart rate, logarithmic transformed plasma BNP, greater than 1 year after onset of MI, Doppler-derived estimated pulmonary vascular resistance, LV systolic indices, LV mass index, infarcted segments within a territory of the left circumflex artery and residual total occlusion in the culprit right coronary artery. Multivariable linear regression analysis indicated that reduced longitudinal LV PSS in the 4-chamber view and BNP levels ≥500 pg/ml were independently associated with reduced global and free wall RV PSS. Moreover, when patients were divided into 3 groups according to plasma BNP levels (BNP <100 pg/ml; n = 31, 100 ≤BNP <500 pg/ml; n = 24, and BNP ≥500 pg/ml; n = 16), only patients with BNP ≥500 pg/ml had a strong correlation between RV PSS and longitudinal LV PSS in the 4-chamber view (r = 0.78 for global RV PSS and r = 0.71 for free wall RV PSS, p <0.05). CONCLUSION: Longitudinal RV systolic strain depends significantly on longitudinal LV systolic strain especially in patients with high plasma BNP levels, but not on estimated peak systolic pulmonary artery pressure. These results indicate that process of RV myocardial dysfunction following MI may be governed by neurohormonal activation which causing ventricular remodeling rather than increased RV afterload.
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spelling pubmed-37007562013-07-04 Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography Konishi, Katsuhisa Dohi, Kaoru Tanimura, Muneyoshi Sato, Yuichi Watanabe, Kiyotaka Sugiura, Emiyo Kumagai, Naoto Nakamori, Shiro Nakajima, Hiroshi Yamada, Tomomi Onishi, Katsuya Nakamura, Mashio Nobori, Tsutomu Ito, Masaaki Cardiovasc Ultrasound Research BACKGROUND: We investigated longitudinal right ventricular (RV) function assessed using speckle-tracking strain echocardiography in patient with myocardial infarction (MI), and identified the contributing factors for RV dysfunction. METHODS: We retrospectively studied 71 patients with old MI (the OMI group) and 45 normal subjects (the Control group) who underwent a transthoracic echocardiography. Global and free wall RV peak systolic strains (PSSs) in the longitudinal direction were measured by using speckle-tracking strain echocardiography. Left ventricular (LV) PSSs were measured in the longitudinal, radial and circumferential directions. Cardiac hemodynamics including peak systolic pulmonary artery pressure was also assessed non-invasively. Plasma brain natriuretic peptide (BNP) levels were measured in all patients. RESULTS: In the OMI group, 73% of the patients had a normal estimated peak systolic pulmonary artery pressure of less than 35 mmHg. Global and free wall RV PSS were impaired in the OMI group compared with the Control group, and these RV systolic indices were significantly associated with heart rate, logarithmic transformed plasma BNP, greater than 1 year after onset of MI, Doppler-derived estimated pulmonary vascular resistance, LV systolic indices, LV mass index, infarcted segments within a territory of the left circumflex artery and residual total occlusion in the culprit right coronary artery. Multivariable linear regression analysis indicated that reduced longitudinal LV PSS in the 4-chamber view and BNP levels ≥500 pg/ml were independently associated with reduced global and free wall RV PSS. Moreover, when patients were divided into 3 groups according to plasma BNP levels (BNP <100 pg/ml; n = 31, 100 ≤BNP <500 pg/ml; n = 24, and BNP ≥500 pg/ml; n = 16), only patients with BNP ≥500 pg/ml had a strong correlation between RV PSS and longitudinal LV PSS in the 4-chamber view (r = 0.78 for global RV PSS and r = 0.71 for free wall RV PSS, p <0.05). CONCLUSION: Longitudinal RV systolic strain depends significantly on longitudinal LV systolic strain especially in patients with high plasma BNP levels, but not on estimated peak systolic pulmonary artery pressure. These results indicate that process of RV myocardial dysfunction following MI may be governed by neurohormonal activation which causing ventricular remodeling rather than increased RV afterload. BioMed Central 2013-06-27 /pmc/articles/PMC3700756/ /pubmed/23802850 http://dx.doi.org/10.1186/1476-7120-11-23 Text en Copyright © 2013 Konishi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Konishi, Katsuhisa
Dohi, Kaoru
Tanimura, Muneyoshi
Sato, Yuichi
Watanabe, Kiyotaka
Sugiura, Emiyo
Kumagai, Naoto
Nakamori, Shiro
Nakajima, Hiroshi
Yamada, Tomomi
Onishi, Katsuya
Nakamura, Mashio
Nobori, Tsutomu
Ito, Masaaki
Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
title Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
title_full Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
title_fullStr Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
title_full_unstemmed Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
title_short Quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
title_sort quantifying longitudinal right ventricular dysfunction in patients with old myocardial infarction by using speckle-tracking strain echocardiography
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700756/
https://www.ncbi.nlm.nih.gov/pubmed/23802850
http://dx.doi.org/10.1186/1476-7120-11-23
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