Mutations in variable domains of the HIV-1 envelope gene can have a significant impact on maraviroc and vicriviroc resistance

BACKGROUND: Resistance to CCR5 inhibitors, such as maraviroc and vicriviroc is characterized by reduction of maximal percent inhibition which indicates the use of an inhibitor-bound conformation of CCR5 for human immunodeficiency virus-1(HIV-1) entry. It is accompanied by substitutions in gp120 and...

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Detalles Bibliográficos
Autores principales: Asin-Milan, Odalis, Chamberland, Annie, Wei, Yi, Haidara, Alpha, Sylla, Mohamed, Tremblay, Cécile L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700831/
https://www.ncbi.nlm.nih.gov/pubmed/23758814
http://dx.doi.org/10.1186/1742-6405-10-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700831/
https://www.ncbi.nlm.nih.gov/pubmed/23758814
http://dx.doi.org/10.1186/1742-6405-10-15

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