Sensitization of ovarian carcinoma cells to Bcl-x(L)-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

BACKGROUND: Our work has been carried out in the context of the therapeutic failure in ovarian carcinoma, which remains the leading cause of death by gynecologic malignancy. In these tumours, recurrence and subsequent acquired chemoresistance constitute major hurdles to successful therapy. Here we s...

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Detalles Bibliográficos
Autores principales: Tomasina, Julie, Malzert-Freon, Aurélie, Giffard, Florence, Brotin, Emilie, Louis, Marie-Hélène, Abeilard, Edwige, Rault, Sylvain, Gauduchon, Pascal, Poulain, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700836/
https://www.ncbi.nlm.nih.gov/pubmed/23735052
http://dx.doi.org/10.1186/1757-2215-6-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700836/
https://www.ncbi.nlm.nih.gov/pubmed/23735052
http://dx.doi.org/10.1186/1757-2215-6-38

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