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Fitness Loss and Library Size Determination in Saturation Mutagenesis
Saturation mutagenesis is a widely used directed evolution technique, in which a large number of protein variants, each having random amino acids in certain predetermined positions, are screened in order to discover high-fitness variants among them. Several metrics for determining the library size (...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700877/ https://www.ncbi.nlm.nih.gov/pubmed/23844158 http://dx.doi.org/10.1371/journal.pone.0068069 |