Exosome-Bound WD Repeat Protein Monad Inhibits Breast Cancer Cell Invasion by Degrading Amphiregulin mRNA

Increased stabilization of mRNA coding for key cancer genes can contribute to invasiveness. This is achieved by down-regulation of exosome cofactors, which bind to 3'-UTR in cancer-related genes. Here, we identified amphiregulin, an EGFR ligand, as a target of WD repeat protein Monad, a compone...

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Detalles Bibliográficos
Autores principales: Saeki, Makio, Egusa, Hiroshi, Kamano, Yuya, Kakihara, Yoshito, Houry, Walid A., Yatani, Hirofumi, Noguchi, Shinzaburo, Kamisaki, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701000/
https://www.ncbi.nlm.nih.gov/pubmed/23844004
http://dx.doi.org/10.1371/journal.pone.0067326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701000/
https://www.ncbi.nlm.nih.gov/pubmed/23844004
http://dx.doi.org/10.1371/journal.pone.0067326

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