Methylation of the Claudin 1 Promoter Is Associated with Loss of Expression in Estrogen Receptor Positive Breast Cancer

Downregulation of the tight junction protein claudin 1 is a frequent event in breast cancer and is associated with recurrence, metastasis, and reduced survival, suggesting a tumor suppressor role for this protein. Tumor suppressor genes are often epigenetically silenced in cancer. Downregulation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Cello, Francescopaolo, Cope, Leslie, Li, Huili, Jeschke, Jana, Wang, Wei, Baylin, Stephen B., Zahnow, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701071/
https://www.ncbi.nlm.nih.gov/pubmed/23844228
http://dx.doi.org/10.1371/journal.pone.0068630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701071/
https://www.ncbi.nlm.nih.gov/pubmed/23844228
http://dx.doi.org/10.1371/journal.pone.0068630

Ejemplares similares