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Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity
Active-site serine D,D-transpeptidases belonging to the penicillin-binding protein family (PBPs) have been considered for a long time as essential for peptidoglycan cross-linking in all bacteria. However, bypass of the PBPs by an L,D-transpeptidase (Ldt(fm)) conveys high-level resistance to β-lactam...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701632/ https://www.ncbi.nlm.nih.gov/pubmed/23861815 http://dx.doi.org/10.1371/journal.pone.0067831 |