Cargando…

Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity

Active-site serine D,D-transpeptidases belonging to the penicillin-binding protein family (PBPs) have been considered for a long time as essential for peptidoglycan cross-linking in all bacteria. However, bypass of the PBPs by an L,D-transpeptidase (Ldt(fm)) conveys high-level resistance to β-lactam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Triboulet, Sébastien, Dubée, Vincent, Lecoq, Lauriane, Bougault, Catherine, Mainardi, Jean-Luc, Rice, Louis B., Ethève-Quelquejeu, Mélanie, Gutmann, Laurent, Marie, Arul, Dubost, Lionel, Hugonnet, Jean-Emmanuel, Simorre, Jean-Pierre, Arthur, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701632/ https://www.ncbi.nlm.nih.gov/pubmed/23861815 http://dx.doi.org/10.1371/journal.pone.0067831

Ejemplares similares

Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site
por: Edoo, Zainab, et al.
Publicado: (2017)

Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis
por: Villet, Régis, et al.
Publicado: (2007)

Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli
por: Hugonnet, Jean-Emmanuel, et al.
Publicado: (2016)

Recognition of Peptidoglycan Fragments by the Transpeptidase PBP4 From Staphylococcus aureus
por: Maya-Martinez, Roberto, et al.
Publicado: (2019)

Serine/Threonine Protein Phosphatase-Mediated Control of the Peptidoglycan Cross-Linking l,d-Transpeptidase Pathway in Enterococcus faecium
por: Sacco, Emmanuelle, et al.
Publicado: (2014)

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase
por: Ahmad, Nazia, et al.
Publicado: (2022)

Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams
por: Qiao, Yuan, et al.
Publicado: (2017)

Characterization of Pseudomonas aeruginosa l,d-Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth
por: Hugonneau-Beaufet, Inès, et al.
Publicado: (2023)

Non-classical transpeptidases yield insight into new antibacterials
por: Kumar, Pankaj, et al.
Publicado: (2016)

Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications
por: Polikanov, Yury S., et al.
Publicado: (2023)

The Mycobacterium tuberculosis gene, ldt(Mt2), encodes a non-classical transpeptidase required for virulence and resistance to amoxicillin
por: Gupta, Radhika, et al.
Publicado: (2010)

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae
por: Li, Yuan, et al.
Publicado: (2016)

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials
por: Sauvage, Eric, et al.
Publicado: (2016)

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
por: Lohans, Christopher T., et al.
Publicado: (2019)

A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase Ldt(Mt2)
por: de Munnik, Mariska, et al.
Publicado: (2019)

A Peptidoglycan Fragment Triggers β-lactam Resistance in Bacillus licheniformis
por: Amoroso, Ana, et al.
Publicado: (2012)

Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of β-lactams
por: Voedts, Henri, et al.
Publicado: (2022)

Solution NMR assignment of LpoB, an outer-membrane anchored Penicillin-Binding Protein activator from Escherichia coli
por: Jean, Nicolas L., et al.
Publicado: (2014)

Aminoacyl-tRNA recognition by the FemX(Wv) transferase for bacterial cell wall synthesis
por: Fonvielle, Matthieu, et al.
Publicado: (2009)

Synthesis of Triazole-Linked SAM-Adenosine Conjugates: Functionalization of Adenosine at N-1 or N-6 Position without Protecting Groups
por: Atdjian, Colette, et al.
Publicado: (2020)

Enzymatic Synthesis of Vancomycin-Modified DNA
por: Figazzolo, Chiara, et al.
Publicado: (2022)

Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli
por: Caveney, Nathanael A., et al.
Publicado: (2019)

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt(Mt2) by biapenem and tebipenem
por: Bianchet, Mario A., et al.
Publicado: (2017)

Partition of tRNA(Gly) isoacceptors between protein and cell-wall peptidoglycan synthesis in Staphylococcus aureus
por: Rietmeyer, Lauriane, et al.
Publicado: (2020)

Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against β-lactam antibiotics
por: Boudet, Julien, et al.
Publicado: (2007)

Staphylococcus aureus sacculus mediates activities of M23 hydrolases
por: Razew, Alicja, et al.
Publicado: (2023)

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases
por: Lopez Quezada, Landys, et al.
Publicado: (2020)

Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population
por: Chen, Weijie, et al.
Publicado: (2022)

Structure–function analysis of the extracellular domain of the pneumococcal cell division site positioning protein MapZ
por: Manuse, Sylvie, et al.
Publicado: (2016)

An Electrochemical Method to Detect Gamma Glutamyl Transpeptidase
por: Chen, Guifang, et al.
Publicado: (2012)

Role of Campylobacter jejuni gamma-glutamyl transpeptidase on epithelial cell apoptosis and lymphocyte proliferation
por: Floch, Pauline, et al.
Publicado: (2014)

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis
por: Rietmeyer, Lauriane, et al.
Publicado: (2022)

Evaluation of the Antibacterial Activities of Mangrove Honeybee Propolis Extract and the Identification of Transpeptidase and Transglycosylase as Targets for New Antibiotics Using Molecular Docking
por: Alshiekheid, Maha A.
Publicado: (2023)

Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly
por: Laguri, Cedric, et al.
Publicado: (2017)

The clinical implication of gamma-glutamyl transpeptidase in COVID-19()
por: Liu, Jianrong, et al.
Publicado: (2021)

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection
por: Rullas, Joaquín, et al.
Publicado: (2015)

Induced conformational changes activate the peptidoglycan synthase PBP1B
por: Egan, Alexander J. F., et al.
Publicado: (2018)

Structural features of the interaction of MapZ with FtsZ and membranes in Streptococcus pneumoniae
por: Hosek, Tomas, et al.
Publicado: (2020)

2806. The Mechanism of β-Lactam Antibiotic Action: Structural Analysis of Mycobacterium abscessus l,d-Transpeptidases, d,d-Carboxypeptidase and penicillin-binding-proteins binding by imipenem, ceftaroline, and amoxicillin
por: Shin, Eunjeong, et al.
Publicado: (2023)

Elongated Structure of the Outer-Membrane Activator of Peptidoglycan Synthesis LpoA: Implications for PBP1A Stimulation
por: Jean, Nicolas L., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_l73irife9akpj11tsv7nvgmaih