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Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and The Korean Society for Cytopathology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701821/ https://www.ncbi.nlm.nih.gov/pubmed/23837018 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.252 |
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author | Ha, Seung Yeon Ahn, Jungsuk Roh, Mee Sook Han, Joungho Lee, Jae Jun Lee, Boin Yim, Jun |
author_facet | Ha, Seung Yeon Ahn, Jungsuk Roh, Mee Sook Han, Joungho Lee, Jae Jun Lee, Boin Yim, Jun |
author_sort | Ha, Seung Yeon |
collection | PubMed |
description | BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. RESULTS: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. CONCLUSIONS: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001). |
format | Online Article Text |
id | pubmed-3701821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Pathologists and The Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-37018212013-07-08 Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma Ha, Seung Yeon Ahn, Jungsuk Roh, Mee Sook Han, Joungho Lee, Jae Jun Lee, Boin Yim, Jun Korean J Pathol Original Article BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. RESULTS: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. CONCLUSIONS: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001). The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-06 2013-06-25 /pmc/articles/PMC3701821/ /pubmed/23837018 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.252 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ha, Seung Yeon Ahn, Jungsuk Roh, Mee Sook Han, Joungho Lee, Jae Jun Lee, Boin Yim, Jun Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma |
title | Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma |
title_full | Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma |
title_fullStr | Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma |
title_full_unstemmed | Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma |
title_short | Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma |
title_sort | cytologic features of alk-positive pulmonary adenocarcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701821/ https://www.ncbi.nlm.nih.gov/pubmed/23837018 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.252 |
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