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Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma

BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases...

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Autores principales: Ha, Seung Yeon, Ahn, Jungsuk, Roh, Mee Sook, Han, Joungho, Lee, Jae Jun, Lee, Boin, Yim, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701821/
https://www.ncbi.nlm.nih.gov/pubmed/23837018
http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.252
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author Ha, Seung Yeon
Ahn, Jungsuk
Roh, Mee Sook
Han, Joungho
Lee, Jae Jun
Lee, Boin
Yim, Jun
author_facet Ha, Seung Yeon
Ahn, Jungsuk
Roh, Mee Sook
Han, Joungho
Lee, Jae Jun
Lee, Boin
Yim, Jun
author_sort Ha, Seung Yeon
collection PubMed
description BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. RESULTS: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. CONCLUSIONS: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
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spelling pubmed-37018212013-07-08 Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma Ha, Seung Yeon Ahn, Jungsuk Roh, Mee Sook Han, Joungho Lee, Jae Jun Lee, Boin Yim, Jun Korean J Pathol Original Article BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. RESULTS: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. CONCLUSIONS: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001). The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-06 2013-06-25 /pmc/articles/PMC3701821/ /pubmed/23837018 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.252 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ha, Seung Yeon
Ahn, Jungsuk
Roh, Mee Sook
Han, Joungho
Lee, Jae Jun
Lee, Boin
Yim, Jun
Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
title Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
title_full Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
title_fullStr Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
title_full_unstemmed Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
title_short Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
title_sort cytologic features of alk-positive pulmonary adenocarcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701821/
https://www.ncbi.nlm.nih.gov/pubmed/23837018
http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.252
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