Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study

BACKGROUND: N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer's disease (AD). pE3-Aβ deposition is also found in AD-like transgenic (tg) mouse brain, albeit in lesser qu...

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Detalles Bibliográficos
Autores principales: Frost, Jeffrey L., Liu, Bin, Kleinschmidt, Martin, Schilling, Stephan, Demuth, Hans-Ulrich, Lemere, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702016/
https://www.ncbi.nlm.nih.gov/pubmed/22343072
http://dx.doi.org/10.1159/000335913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702016/
https://www.ncbi.nlm.nih.gov/pubmed/22343072
http://dx.doi.org/10.1159/000335913

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