Validity, Significance, Strengths, Limitations, and Evidentiary Value of Real-World Clinical Data for Combination Therapy in Alzheimer's Disease: Comparison of Efficacy and Effectiveness Studies

BACKGROUND: Randomized controlled efficacy trials (RCTs), the scientific gold standard, are required for regulatory approval of Alzheimer's disease (AD) interventions, yet provide limited information regarding real-world therapeutic effectiveness. Objective: To compare the nature of evidence re...

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Detalles Bibliográficos
Autores principales: Atri, Alireza, Rountree, Susan D., Lopez, Oscar L., Doody, Rachelle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702018/
https://www.ncbi.nlm.nih.gov/pubmed/22327239
http://dx.doi.org/10.1159/000335156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702018/
https://www.ncbi.nlm.nih.gov/pubmed/22327239
http://dx.doi.org/10.1159/000335156

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