Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active drug discovery and clinical investigation. Trials of personalized cancer therapy seek to leverage knowledge of cancer gene mutations by using m...

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Detalles Bibliográficos
Autores principales: Yi, Kyung H., Axtmayer, Jossette, Gustin, John P., Rajpurohit, Anandita, Lauring, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702205/
https://www.ncbi.nlm.nih.gov/pubmed/23237847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702205/
https://www.ncbi.nlm.nih.gov/pubmed/23237847

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