Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction

RIP1 is a serine/threonine kinase, which is involved in apoptosis and necroptosis. In apoptosis, caspase-8 and FADD have an important role. On the other hand, RIP3 is a key molecule in necroptosis. Recently, we reported that eleostearic acid (ESA) elicits caspase-3- and PARP-1-independent cell death...

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Detalles Bibliográficos
Autores principales: Obitsu, S, Sakata, K, Teshima, R, Kondo, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702295/
https://www.ncbi.nlm.nih.gov/pubmed/23788031
http://dx.doi.org/10.1038/cddis.2013.188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702295/
https://www.ncbi.nlm.nih.gov/pubmed/23788031
http://dx.doi.org/10.1038/cddis.2013.188

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