Cargando…

ATP citrate lyase knockdown impacts cancer stem cells in vitro

ATP citrate lyase (ACL) knockdown (KD) causes tumor suppression and induces differentiation. We have previously reported that ACL KD reverses epithelial–mesenchymal transition (EMT) in lung cancer cells. Because EMT is often associated with processes that induce stemness, we hypothesized that ACL KD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanai, J-i, Doro, N, Seth, P, Sukhatme, V P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702307/ https://www.ncbi.nlm.nih.gov/pubmed/23807225 http://dx.doi.org/10.1038/cddis.2013.215

Ejemplares similares

Allosteric role of the citrate synthase homology domain of ATP citrate lyase
por: Wei, Xuepeng, et al.
Publicado: (2023)

Exploring the Role of ATP-Citrate Lyase in the Immune System
por: Dominguez, Monica, et al.
Publicado: (2021)

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
por: Baardman, Jeroen, et al.
Publicado: (2020)

ATP-citrate lyase promotes axonal transport across species
por: Even, Aviel, et al.
Publicado: (2021)

Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis
por: Puccini, Joseph, et al.
Publicado: (2023)

Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase
por: Bilen, Ozlem, et al.
Publicado: (2016)

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes
por: Verberk, Sanne G. S., et al.
Publicado: (2021)

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase
por: Namgaladze, Dmitry, et al.
Publicado: (2018)

Publisher Correction: ATP-citrate lyase promotes axonal transport across species
por: Even, Aviel, et al.
Publicado: (2021)

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion
por: El Azzouny, Mahmoud, et al.
Publicado: (2016)

Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer
por: WANG, YU, et al.
Publicado: (2012)

Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling
por: Gao, Yajuan, et al.
Publicado: (2015)

Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer
por: Xie, Shuang, et al.
Publicado: (2015)

Overexpression of ATP citrate lyase in renal cell carcinoma tissues and its effect on the human renal carcinoma cells in vitro
por: Teng, Lichen, et al.
Publicado: (2018)

Correlation of ATP Citrate Lyase and Acetyl CoA Levels with Trichothecene Production in Fusarium graminearum
por: Sakamoto, Naoko, et al.
Publicado: (2013)

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
por: Kumari, Rajni, et al.
Publicado: (2019)

Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles
por: Wang, Pan, et al.
Publicado: (2022)

ATP-citrate lyase B (ACLB) negatively affects cell death and resistance to Verticillium wilt
por: Liu, Fujie, et al.
Publicado: (2022)

Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly
por: Csanadi, Agnes, et al.
Publicado: (2015)

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
por: Pinkosky, Stephen L., et al.
Publicado: (2016)

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
por: Ren, Jian-Guo, et al.
Publicado: (2017)

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
por: Martinez Calejman, C., et al.
Publicado: (2020)

Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells
por: Hatipoglu, Ahmet, et al.
Publicado: (2022)

ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae
por: Rodriguez, Sarah, et al.
Publicado: (2016)

Enhancement of docosahexaenoic acid production by overexpression of ATP-citrate lyase and acetyl-CoA carboxylase in Schizochytrium sp.
por: Han, Xiao, et al.
Publicado: (2020)

Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger
por: Hossain, Abeer H., et al.
Publicado: (2019)

ER resident protein 44 promotes malignant phenotype in nasopharyngeal carcinoma through the interaction with ATP citrate lyase
por: Tian, Hui, et al.
Publicado: (2021)

ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model
por: Zhan, Zishun, et al.
Publicado: (2022)

ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury
por: Li, Ranran, et al.
Publicado: (2023)

S108: ATP CITRATE LYASE IS AN ESSENTIAL PLAYER OF THE METABOLIC REWIRING INDUCED BY PTEN LOSS DURING T-ALL DEVELOPMENT
por: Andrieu, Guillaume, et al.
Publicado: (2023)

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation
por: Zheng, Wei, et al.
Publicado: (2021)

Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells
por: Morciano, Patrizia, et al.
Publicado: (2019)

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker
por: Göttgens, Eva-Leonne, et al.
Publicado: (2019)

Author Correction: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
por: Calejman, C. Martinez, et al.
Publicado: (2020)

Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells
por: Dominguez, Monica, et al.
Publicado: (2022)

miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer
por: Xin, Mei, et al.
Publicado: (2016)

The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis
por: Di Giorgio, Maria Laura, et al.
Publicado: (2020)

Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice
por: Yenilmez, Batuhan, et al.
Publicado: (2022)

Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase
por: Qiu, Zhendong, et al.
Publicado: (2021)

In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis
por: Siculella, Luisa, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pqiiaf0c51dhf7j53m19fo8526