DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control

BACKGROUND: The p53 pathway is differentially activated in response to distinct DNA damage, leading to alternative phenotypic outcomes in mammalian cells. Recent evidence suggests that p53 expression dynamics play an important role in the differential regulation of cell fate, but questions remain as...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Chen, Jia, Gan, Siting, Guan, Huaji, Zhou, Yuan, Ouyang, Qi, Shi, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702437/
https://www.ncbi.nlm.nih.gov/pubmed/23800173
http://dx.doi.org/10.1186/1741-7007-11-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702437/
https://www.ncbi.nlm.nih.gov/pubmed/23800173
http://dx.doi.org/10.1186/1741-7007-11-73

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