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DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
BACKGROUND: The p53 pathway is differentially activated in response to distinct DNA damage, leading to alternative phenotypic outcomes in mammalian cells. Recent evidence suggests that p53 expression dynamics play an important role in the differential regulation of cell fate, but questions remain as...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702437/ https://www.ncbi.nlm.nih.gov/pubmed/23800173 http://dx.doi.org/10.1186/1741-7007-11-73 |