Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

RECQL5 is a member of the highly conserved RecQ family of DNA helicases involved in DNA repair. RECQL5 interacts with RNA polymerase II (Pol II) and inhibits transcription of protein–coding genes by an unknown mechanism. We show that RECQL5 contacts the Rpb1 jaw domain of Pol II at a site that overl...

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Detalles Bibliográficos
Autores principales: Kassube, Susanne A., Jinek, Martin, Fang, Jie, Tsutakawa, Susan, Nogales, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702667/
https://www.ncbi.nlm.nih.gov/pubmed/23748380
http://dx.doi.org/10.1038/nsmb.2596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702667/
https://www.ncbi.nlm.nih.gov/pubmed/23748380
http://dx.doi.org/10.1038/nsmb.2596

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