Cargando…

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

RECQL5 is a member of the highly conserved RecQ family of DNA helicases involved in DNA repair. RECQL5 interacts with RNA polymerase II (Pol II) and inhibits transcription of protein–coding genes by an unknown mechanism. We show that RECQL5 contacts the Rpb1 jaw domain of Pol II at a site that overl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kassube, Susanne A., Jinek, Martin, Fang, Jie, Tsutakawa, Susan, Nogales, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702667/ https://www.ncbi.nlm.nih.gov/pubmed/23748380 http://dx.doi.org/10.1038/nsmb.2596

Ejemplares similares

Direct Inhibition of RNA Polymerase II Transcription by RECQL5
por: Aygün, Ozan, et al.
Publicado: (2009)

RECQL: a DNA helicase in breast cancer
por: Akbari, Mohammad R., et al.
Publicado: (2015)

Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members – RECQL, BLM, WRN, RECQL4, and RECQL5 – in patients with breast cancer
por: Zhu, Xuan, et al.
Publicado: (2018)

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
por: Newman, Joseph A., et al.
Publicado: (2017)

Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy
por: Patterson, Karl, et al.
Publicado: (2016)

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
por: Ng, Alvin J. M., et al.
Publicado: (2015)

RECQL5 at the Intersection of Replication and Transcription
por: Hamadeh, Zeid, et al.
Publicado: (2020)

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase
por: Popuri, Venkateswarlu, et al.
Publicado: (2013)

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase
por: Popuri, Venkateswarlu, et al.
Publicado: (2017)

RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis
por: Fang, Hongbo, et al.
Publicado: (2013)

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
por: Abu-Libdeh, Bassam, et al.
Publicado: (2022)

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4
por: Castillo-Tandazo, Wilson, et al.
Publicado: (2019)

The RECQL helicase prevents replication fork collapse during replication stress
por: Benedict, Bente, et al.
Publicado: (2020)

The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif
por: Ohlenschläger, Oliver, et al.
Publicado: (2012)

RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers
por: Futami, Kazunobu, et al.
Publicado: (2015)

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression
por: Ramamoorthy, Mahesh, et al.
Publicado: (2012)

Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy
por: Hussain, Mansoor, et al.
Publicado: (2023)

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability
por: Singh, Dharmendra Kumar, et al.
Publicado: (2012)

The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients
por: Jensen, Martin Borch, et al.
Publicado: (2012)

Human RECQL5 participates in the removal of endogenous DNA damage
por: Tadokoro, Takashi, et al.
Publicado: (2012)

RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer
por: Sanada, Sakiko, et al.
Publicado: (2013)

RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress
por: Saponaro, Marco, et al.
Publicado: (2014)

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication
por: Tsutakawa, Susan E., et al.
Publicado: (2021)

DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication
por: Lo, Chen-Yu, et al.
Publicado: (2021)

A Large Case-Control Study Performed in Spanish Population Suggests That RECQL5 Is the Only RECQ Helicase Involved in Breast Cancer Susceptibility
por: Marchena-Perea, Erik Michel, et al.
Publicado: (2022)

Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells
por: Król, Sylwia K., et al.
Publicado: (2020)

Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer
por: Gupta, Pooja, et al.
Publicado: (2022)

Human RECQL5β stimulates flap endonuclease 1
por: Speina, Elżbieta, et al.
Publicado: (2010)

RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription
por: Kanagaraj, Radhakrishnan, et al.
Publicado: (2010)

DNA Polymerase-Parental DNA Interaction Is Essential for Helicase-Polymerase Coupling during Bacteriophage T7 DNA Replication
por: Lo, Chen-Yu, et al.
Publicado: (2022)

Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer
por: Sun, Jie, et al.
Publicado: (2015)

RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer
por: Lyu, Guosheng, et al.
Publicado: (2021)

Human RECQL1 participates in telomere maintenance
por: Popuri, Venkateswarlu, et al.
Publicado: (2014)

Human RECQL1 participates in telomere maintenance
por: Popuri, Venkateswarlu, et al.
Publicado: (2017)

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
por: Andrs, Martin, et al.
Publicado: (2020)

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity
por: Kim, Hyunsup, et al.
Publicado: (2021)

Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities
por: Sebesta, Marek, et al.
Publicado: (2011)

RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway
por: Kim, Tae Moon, et al.
Publicado: (2015)

RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway
por: Zhou, Fei, et al.
Publicado: (2021)

Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
por: de Lima, Loyze P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hoc80stbdin3q5l2rvac7su8j5