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Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway
[Image: see text] The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. The molecular characterization of the pathway, which has been enabled by small-molecule probes targeting its comp...
Autores principales: | Schaefer, Giannina I., Perez, José R., Duvall, Jeremy R., Stanton, Benjamin Z., Shamji, Alykhan F., Schreiber, Stuart L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703668/ https://www.ncbi.nlm.nih.gov/pubmed/23725514 http://dx.doi.org/10.1021/ja400034k |
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