Catalytic-independent roles of UTX-1 in C. elegans development

We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is...

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Detalles Bibliográficos
Autores principales: Vandamme, Julien, Salcini, Anna Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704440/
https://www.ncbi.nlm.nih.gov/pubmed/24058866
http://dx.doi.org/10.4161/worm.22188
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author Vandamme, Julien
Salcini, Anna Elisabetta
author_facet Vandamme, Julien
Salcini, Anna Elisabetta
author_sort Vandamme, Julien
collection PubMed
description We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.
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spelling pubmed-37044402013-09-19 Catalytic-independent roles of UTX-1 in C. elegans development Vandamme, Julien Salcini, Anna Elisabetta Worm Commentary We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3704440/ /pubmed/24058866 http://dx.doi.org/10.4161/worm.22188 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Vandamme, Julien
Salcini, Anna Elisabetta
Catalytic-independent roles of UTX-1 in C. elegans development
title Catalytic-independent roles of UTX-1 in C. elegans development
title_full Catalytic-independent roles of UTX-1 in C. elegans development
title_fullStr Catalytic-independent roles of UTX-1 in C. elegans development
title_full_unstemmed Catalytic-independent roles of UTX-1 in C. elegans development
title_short Catalytic-independent roles of UTX-1 in C. elegans development
title_sort catalytic-independent roles of utx-1 in c. elegans development
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704440/
https://www.ncbi.nlm.nih.gov/pubmed/24058866
http://dx.doi.org/10.4161/worm.22188
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