Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation

The Hedgehog pathway is activated in various types of malignancies. We previously reported that inhibition of SMO or GLI prevents osteosarcoma growth in vitro and in vivo. Recently, it has been reported that arsenic trioxide (ATO) inhibits cancer growth by blocking GLI transcription. In this study,...

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Detalles Bibliográficos
Autores principales: Nakamura, Shunsuke, Nagano, Satoshi, Nagao, Hiroko, Ishidou, Yasuhiro, Yokouchi, Masahiro, Abematsu, Masahiko, Yamamoto, Takuya, Komiya, Setsuro, Setoguchi, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704531/
https://www.ncbi.nlm.nih.gov/pubmed/23861973
http://dx.doi.org/10.1371/journal.pone.0069466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704531/
https://www.ncbi.nlm.nih.gov/pubmed/23861973
http://dx.doi.org/10.1371/journal.pone.0069466

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