Modes of Action of ADP-Ribosylated Elongation Factor 2 in Inhibiting the Polypeptide Elongation Cycle: A Modeling Study

Despite the fact that ADP-ribosylation of eukaryotic elongation factor 2 (EF2) leads to inhibition of protein synthesis, the mechanism by which ADP-ribosylated EF2 (ADPR•EF2) causes this inhibition remains controversial. Here, we applied modeling approaches to investigate the consequences of various...

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Detalles Bibliográficos
Autores principales: Chen, Kevin C., Xie, Honglin, Cai, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704607/
https://www.ncbi.nlm.nih.gov/pubmed/23861744
http://dx.doi.org/10.1371/journal.pone.0066446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704607/
https://www.ncbi.nlm.nih.gov/pubmed/23861744
http://dx.doi.org/10.1371/journal.pone.0066446

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