Flt-1 in colorectal cancer cells is required for the tumor invasive effect of placental growth factor through a p38-MMP9 pathway

BACKGROUND: Placenta growth factor (PlGF), a dimeric glycoprotein with 53% homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and may function by modulating VEGF activity. We previously have showed that PlGF displays prognostic value in colorectal cancer (CRC) bu...

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Detalles Bibliográficos
Autores principales: Wei, Shu-Chen, Tsao, Po-Nien, Weng, Meng-Tzu, Cao, Zhifang, Wong, Jau-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704813/
https://www.ncbi.nlm.nih.gov/pubmed/23799978
http://dx.doi.org/10.1186/1423-0127-20-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704813/
https://www.ncbi.nlm.nih.gov/pubmed/23799978
http://dx.doi.org/10.1186/1423-0127-20-39

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