Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

BACKGROUND: In the progression towards diabetes, glucolipotoxicity is one of the main causes of pancreatic beta cell pathology. The aim of this study was to examine the in vitro effects of chronic glucolipotoxic conditions on cellular responses in pancreatic islets, including glucose and fat metabol...

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Detalles Bibliográficos
Autores principales: Somesh, Baggavalli P, Verma, Mahesh Kumar, Sadasivuni, Manoj Kumar, Mammen-Oommen, Anup, Biswas, Sanghamitra, Shilpa, Pavagada C, Reddy, Ashok Kumar, Yateesh, Aggunda N, Pallavi, Puttrevana M, Nethra, Siddaraju, Smitha, Rachapalli, Neelima, Korrapati, Narayanan, Usha, Jagannath, Madanahalli R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704974/
https://www.ncbi.nlm.nih.gov/pubmed/23815372
http://dx.doi.org/10.1186/1471-2121-14-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704974/
https://www.ncbi.nlm.nih.gov/pubmed/23815372
http://dx.doi.org/10.1186/1471-2121-14-31

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