Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

The tumor suppressor gene p53 has been implicated in the regulation of epithelial–mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) expression. Here, we report that mutant p53 exerts oncogenic functions and promotes EMT in endometrial cancer (EC) by directly binding to...

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Detalles Bibliográficos
Autores principales: Dong, P, Karaayvaz, M, Jia, N, Kaneuchi, M, Hamada, J, Watari, H, Sudo, S, Ju, J, Sakuragi, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705163/
https://www.ncbi.nlm.nih.gov/pubmed/22847613
http://dx.doi.org/10.1038/onc.2012.334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705163/
https://www.ncbi.nlm.nih.gov/pubmed/22847613
http://dx.doi.org/10.1038/onc.2012.334

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