Cargando…

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the underlying mechanisms of linkage specificity are u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705208/ https://www.ncbi.nlm.nih.gov/pubmed/23827681 http://dx.doi.org/10.1016/j.cell.2013.05.046

Ejemplares similares

Regulation of A20 and other OTU deubiquitinases by reversible oxidation
por: Kulathu, Yogesh, et al.
Publicado: (2013)

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets
por: Flierman, Dennis, et al.
Publicado: (2016)

Identification and characterization of diverse OTU deubiquitinases in bacteria
por: Schubert, Alexander F, et al.
Publicado: (2020)

Catching a DUB in the act: novel ubiquitin-based active site directed probes
por: Ekkebus, Reggy, et al.
Publicado: (2014)

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
por: Ekkebus, Reggy, et al.
Publicado: (2013)

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection
por: Shin, Donghyuk, et al.
Publicado: (2020)

Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
por: Wilde, Mary-Louise, et al.
Publicado: (2023)

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes
por: Geurink, Paul P., et al.
Publicado: (2016)

An Ankyrin-repeat ubiquitin binding domain determines TRABID’s specificity for atypical ubiquitin chains
por: Licchesi, Julien D.F., et al.
Publicado: (2011)

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G
por: Sahtoe, Danny D., et al.
Publicado: (2015)

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity
por: Kim, Robbert Q., et al.
Publicado: (2019)

Viral OTU Deubiquitinases: A Structural and Functional Comparison
por: Bailey-Elkin, Ben A., et al.
Publicado: (2014)

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin**
por: El Oualid, Farid, et al.
Publicado: (2010)

BAP1/ASXL1 recruitment and activation for H2A deubiquitination
por: Sahtoe, Danny D., et al.
Publicado: (2016)

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents
por: Geurink, Paul P, et al.
Publicado: (2012)

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
por: Békés, Miklós, et al.
Publicado: (2016)

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin
por: Keusekotten, Kirstin, et al.
Publicado: (2013)

Assembly, analysis and architecture of atypical ubiquitin chains
por: Hospenthal, Manuela K., et al.
Publicado: (2013)

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages
por: Min, Mingwei, et al.
Publicado: (2015)

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases
por: Pruneda, Jonathan N., et al.
Publicado: (2016)

Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA
por: Luo, Jiwei, et al.
Publicado: (2022)

Regulation of Met1‐linked polyubiquitin signalling by the deubiquitinase OTULIN
por: Elliott, Paul R., et al.
Publicado: (2015)

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity
por: Dzimianski, John V., et al.
Publicado: (2019)

OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
por: Wu, Zhiqiang, et al.
Publicado: (2019)

A family of unconventional deubiquitinases with modular chain specificity determinants
por: Hermanns, Thomas, et al.
Publicado: (2018)

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling
por: Michel, Martin A., et al.
Publicado: (2017)

Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes
por: van Tol, Bianca D. M., et al.
Publicado: (2023)

OTU deubiquitinase 5 inhibits the progression of non‐small cell lung cancer via regulating p53 and PDCD5
por: Kang, Xiao‐yun, et al.
Publicado: (2020)

Histone Deubiquitinase OTU1 Epigenetically Regulates DA1 and DA2, Which Control Arabidopsis Seed and Organ Size
por: Keren, Ido, et al.
Publicado: (2020)

dbOTU3: A new implementation of distribution-based OTU calling
por: Olesen, Scott W., et al.
Publicado: (2017)

Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput
por: Jia, Yuqing, et al.
Publicado: (2022)

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
por: Birsa, Nicol, et al.
Publicado: (2014)

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
por: Teixeira, Felipe Roberti, et al.
Publicado: (2016)

Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2
por: Abdul Rehman, Syed Arif, et al.
Publicado: (2021)

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity
por: Huguenin-Dezot, Nicolas, et al.
Publicado: (2016)

Structure of the human Parkin ligase domain in an autoinhibited state
por: Wauer, Tobias, et al.
Publicado: (2013)

Cocrystallization of ubiquitin–deubiquitinase complexes through disulfide linkage
por: Negron Teron, Kristos I., et al.
Publicado: (2023)

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
por: Mevissen, Tycho E.T., et al.
Publicado: (2023)

Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
por: van der Heden van Noort, Gerbrand J., et al.
Publicado: (2017)

On the use of sequence-quality information in OTU clustering
por: Müller, Robert, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d04tcs4l94ab463otialrt6h34