Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin

2,5-bis(3′-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with mean IC(50) value...

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Detalles Bibliográficos
Autores principales: Carbone, Anna, Parrino, Barbara, Barraja, Paola, Spanò, Virginia, Cirrincione, Girolamo, Diana, Patrizia, Maier, Armin, Kelter, Gerhard, Fiebig, Heinz-Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705363/
https://www.ncbi.nlm.nih.gov/pubmed/23455514
http://dx.doi.org/10.3390/md11030643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705363/
https://www.ncbi.nlm.nih.gov/pubmed/23455514
http://dx.doi.org/10.3390/md11030643

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