A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits Ca(V)2.2 Channels and Displays an Anti-Nociceptive Activity

A novel peptide, RsXXIVA, was isolated from the venom duct of Conus regularis, a worm-hunting species collected in the Sea of Cortez, México. Its primary structure was determined by mass spectrometry and confirmed by automated Edman degradation. This conotoxin contains 40 amino acids and exhibits a...

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Detalles Bibliográficos
Autores principales: Bernáldez, Johanna, Román-González, Sergio A., Martínez, Oscar, Jiménez, Samanta, Vivas, Oscar, Arenas, Isabel, Corzo, Gerardo, Arreguín, Roberto, García, David E., Possani, Lourival D., Licea, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705398/
https://www.ncbi.nlm.nih.gov/pubmed/23567319
http://dx.doi.org/10.3390/md11041188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705398/
https://www.ncbi.nlm.nih.gov/pubmed/23567319
http://dx.doi.org/10.3390/md11041188

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