Cargando…

A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits Ca(V)2.2 Channels and Displays an Anti-Nociceptive Activity

A novel peptide, RsXXIVA, was isolated from the venom duct of Conus regularis, a worm-hunting species collected in the Sea of Cortez, México. Its primary structure was determined by mass spectrometry and confirmed by automated Edman degradation. This conotoxin contains 40 amino acids and exhibits a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernáldez, Johanna, Román-González, Sergio A., Martínez, Oscar, Jiménez, Samanta, Vivas, Oscar, Arenas, Isabel, Corzo, Gerardo, Arreguín, Roberto, García, David E., Possani, Lourival D., Licea, Alexei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705398/ https://www.ncbi.nlm.nih.gov/pubmed/23567319 http://dx.doi.org/10.3390/md11041188

Ejemplares similares

A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target
por: Bernáldez, Johanna, et al.
Publicado: (2016)

The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity
por: Bernáldez-Sarabia, Johanna, et al.
Publicado: (2019)

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes
por: Figueroa-Montiel, Andrea, et al.
Publicado: (2018)

Conotoxin Patenting Trends in Academia and Industry
por: Sanchez-Campos, Noemi, et al.
Publicado: (2022)

In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii
por: De León-Nava, Marco A., et al.
Publicado: (2016)

In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus
por: Figueroa-Montiel, Andrea, et al.
Publicado: (2016)

Discovery Methodology of Novel Conotoxins from Conus Species
por: Fu, Ying, et al.
Publicado: (2018)

Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae
por: Robinson, Samuel D., et al.
Publicado: (2014)

Anti-Ovarian Cancer Conotoxins Identified from Conus Venom
por: Ju, Shuang, et al.
Publicado: (2022)

Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR
por: Liu, Xiujie, et al.
Publicado: (2020)

Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus
por: Armstrong, David A., et al.
Publicado: (2021)

Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus
por: Himaya, S. W. A., et al.
Publicado: (2021)

αD-Conotoxins in Species of the Eastern Pacific: The Case of Conus princeps from Mexico
por: Hernández-Sámano, Arisaí C., et al.
Publicado: (2019)

Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of Conus obscurus
por: Wiere, Sean, et al.
Publicado: (2022)

Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism
por: Margiotta, Francesco, et al.
Publicado: (2022)

High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus
por: Müller, Emilie, et al.
Publicado: (2023)

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi
por: Peigneur, Steve, et al.
Publicado: (2019)

A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus)
por: Huang, Yu, et al.
Publicado: (2017)

Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing
por: Zamora-Bustillos, Roberto, et al.
Publicado: (2021)

Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins
por: Krishnarjuna, Bankala, et al.
Publicado: (2023)

Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K(+) channels: A lentiviral vector approach
por: Okada, Masayoshi, et al.
Publicado: (2019)

High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (Conus quercinus) by Transcriptome Sequencing
por: Gao, Bingmiao, et al.
Publicado: (2018)

Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago
por: Neves, Jorge L. B., et al.
Publicado: (2019)

Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus
por: Bao, Nguyen, et al.
Publicado: (2020)

Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus
por: Zhang, Han, et al.
Publicado: (2022)

Proteomic Analysis of the Predatory Venom of Conus striatus Reveals Novel and Population-Specific κA-Conotoxin SIVC
por: Saintmont, Fabrice, et al.
Publicado: (2022)

Chimeric Peptides from Californiconus californicus and Heterodontus francisci with Antigen-Binding Capacity: A Conotoxin Scaffold to Create Non-Natural Antibodies (NoNaBodies)
por: Dueñas, Salvador, et al.
Publicado: (2023)

High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing
por: Peng, Chao, et al.
Publicado: (2016)

Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom of Conus catus
por: Giribaldi, Julien, et al.
Publicado: (2018)

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides
por: Sousa, Silmara R., et al.
Publicado: (2018)

O1-conotoxin Tx6.7 cloned from the genomic DNA of Conus textile that inhibits calcium currents
por: Zhou, Maojun, et al.
Publicado: (2023)

Ultrastructural and Molecular Changes in the Developing Small Intestine of the Toad Bufo regularis
por: Sakr, S. A., et al.
Publicado: (2014)

Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived from Californiconus californicus, for Treating Type 2 Diabetes
por: Lugo-Fabres, Pavel H., et al.
Publicado: (2021)

Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies
por: Lavergne, Vincent, et al.
Publicado: (2013)

Hormesis effects of phosphorus on the viability of Chlorella regularis cells under nitrogen limitation
por: Fu, Liang, et al.
Publicado: (2019)

A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily
por: Luo, Sulan, et al.
Publicado: (2013)

Characterization of an α 4/7-Conotoxin LvIF from Conus lividus That Selectively Blocks α3β2 Nicotinic Acetylcholine Receptor
por: Guo, Man, et al.
Publicado: (2021)

A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors
por: Rodriguez-Ruiz, Ximena C., et al.
Publicado: (2022)

Scorpions from Mexico: From Species Diversity to Venom Complexity
por: Santibáñez-López, Carlos E., et al.
Publicado: (2015)

Metabolites Re-programming and Physiological Changes Induced in Scenedesmus regularis under Nitrate Treatment
por: Ma, Nyuk-Ling, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ep5hfhv62cgqgv1ap67rek09fc