Effects of Nasal or Pulmonary Delivered Treatments with an Adenovirus Vectored Interferon (mDEF201) on Respiratory and Systemic Infections in Mice Caused by Cowpox and Vaccinia Viruses

An adenovirus 5 vector encoding for mouse interferon alpha, subtype 5 (mDEF201) was evaluated for efficacy against lethal cowpox (Brighton strain) and vaccinia (WR strain) virus respiratory and systemic infections in mice. Two routes of mDEF201 administration were used, nasal sinus (5-µl) and pulmon...

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Detalles Bibliográficos
Autores principales: Smee, Donald F., Wong, Min-Hui, Hurst, Brett L., Ennis, Jane, Turner, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706414/
https://www.ncbi.nlm.nih.gov/pubmed/23874722
http://dx.doi.org/10.1371/journal.pone.0068685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706414/
https://www.ncbi.nlm.nih.gov/pubmed/23874722
http://dx.doi.org/10.1371/journal.pone.0068685

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