Conditional VHL Gene Deletion Causes Hypoglycemic Death Associated with Disproportionately Increased Glucose Uptake by Hepatocytes through an Upregulated IGF-I Receptor

Our conditional VHL knockout (VHL-KO) mice, having VHL gene deletion induced by tamoxifen, developed severe hypoglycemia associated with disproportionately increased storage of PAS-positive substances in the liver and resulted in the death of these mice. This hypoglycemic state was neither due to im...

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Detalles Bibliográficos
Autores principales: Kurabayashi, Atsushi, Kakinuma, Yoshihiko, Morita, Taku, Inoue, Keiji, Sato, Takayuki, Furihata, Mutsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706433/
https://www.ncbi.nlm.nih.gov/pubmed/23874892
http://dx.doi.org/10.1371/journal.pone.0069139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706433/
https://www.ncbi.nlm.nih.gov/pubmed/23874892
http://dx.doi.org/10.1371/journal.pone.0069139

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