New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells

Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac. Diclofenac significantly diminished MYC expression and modulate...

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Detalles Bibliográficos
Autores principales: Gottfried, Eva, Lang, Sven A., Renner, Kathrin, Bosserhoff, Anja, Gronwald, Wolfram, Rehli, Michael, Einhell, Sabine, Gedig, Isabel, Singer, Katrin, Seilbeck, Anton, Mackensen, Andreas, Grauer, Oliver, Hau, Peter, Dettmer, Katja, Andreesen, Reinhard, Oefner, Peter J., Kreutz, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706586/
https://www.ncbi.nlm.nih.gov/pubmed/23874405
http://dx.doi.org/10.1371/journal.pone.0066987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706586/
https://www.ncbi.nlm.nih.gov/pubmed/23874405
http://dx.doi.org/10.1371/journal.pone.0066987

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