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HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity

BACKGROUND AND AIM: The genotype-phenotype interaction in drug-induced liver injury (DILI) is a subject of growing interest. Previous studies have linked amoxicillin-clavulanate (AC) hepatotoxicity susceptibility to specific HLA alleles. In this study we aimed to examine potential associations betwe...

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Detalles Bibliográficos
Autores principales: Stephens, Camilla, López-Nevot, Miguel-Ángel, Ruiz-Cabello, Francisco, Ulzurrun, Eugenia, Soriano, Germán, Romero-Gómez, Manuel, Moreno-Casares, Antonia, Lucena, M. Isabel, Andrade, Raúl J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706603/
https://www.ncbi.nlm.nih.gov/pubmed/23874514
http://dx.doi.org/10.1371/journal.pone.0068111