Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle

INTRODUCTION: Stimulating the commitment of implanted dystrophin+ muscle-derived stem cells (MDSCs) into myogenic, as opposed to lipofibrogenic lineages, is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). METHODS: To examine whether counteracting myostatin, a negative regulat...

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Detalles Bibliográficos
Autores principales: Tsao, James, Vernet, Dolores A, Gelfand, Robert, Kovanecz, Istvan, Nolazco, Gaby, Bruhn, Kevin W, Gonzalez-Cadavid, Nestor F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706886/
https://www.ncbi.nlm.nih.gov/pubmed/23295128
http://dx.doi.org/10.1186/scrt152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706886/
https://www.ncbi.nlm.nih.gov/pubmed/23295128
http://dx.doi.org/10.1186/scrt152

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