Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction

Tumor heterogeneity is a limiting factor in cancer treatment and in the discovery of biomarkers to personalize it. We describe a computational purification tool, ISOpure, which directly addresses the effects of variable contamination by normal tissue in clinical tumor specimens. ISOpure uses a set o...

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Detalles Bibliográficos
Autores principales: Quon, Gerald, Haider, Syed, Deshwar, Amit G, Cui, Ang, Boutros, Paul C, Morris, Quaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706990/
https://www.ncbi.nlm.nih.gov/pubmed/23537167
http://dx.doi.org/10.1186/gm433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706990/
https://www.ncbi.nlm.nih.gov/pubmed/23537167
http://dx.doi.org/10.1186/gm433

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