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Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction

Tumor heterogeneity is a limiting factor in cancer treatment and in the discovery of biomarkers to personalize it. We describe a computational purification tool, ISOpure, which directly addresses the effects of variable contamination by normal tissue in clinical tumor specimens. ISOpure uses a set o...

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Detalles Bibliográficos
Autores principales:	Quon, Gerald, Haider, Syed, Deshwar, Amit G, Cui, Ang, Boutros, Paul C, Morris, Quaid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706990/ https://www.ncbi.nlm.nih.gov/pubmed/23537167 http://dx.doi.org/10.1186/gm433

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