Hypothemicin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

Protein kinases are potentially attractive therapeutic targets for neglected parasitic diseases, including African trypanosomiasis caused by the protozoan, Trypanosoma brucei. How to prioritize T. brucei kinases and quantify their intracellular engagement by small-molecule inhibitors remain unsolved...

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Detalles Bibliográficos
Autores principales: Nishino, Mari, Choy, Jonathan W, Gushwa, Nathan N, Oses-Prieto, Juan A, Koupparis, Kyriacos, Burlingame, Alma L, Renslo, Adam R, McKerrow, James H, Taunton, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707081/
https://www.ncbi.nlm.nih.gov/pubmed/23853713
http://dx.doi.org/10.7554/eLife.00712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707081/
https://www.ncbi.nlm.nih.gov/pubmed/23853713
http://dx.doi.org/10.7554/eLife.00712

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