c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (JNK) plays a crucial role. With a view to opt...

Descripción completa

Detalles Bibliográficos
Autores principales: Muñoz-Alonso, María J., Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M., Muñoz, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707168/
https://www.ncbi.nlm.nih.gov/pubmed/23697951
http://dx.doi.org/10.3390/md11051677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707168/
https://www.ncbi.nlm.nih.gov/pubmed/23697951
http://dx.doi.org/10.3390/md11051677

Ejemplares similares