Cargando…

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (JNK) plays a crucial role. With a view to opt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muñoz-Alonso, María J., Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M., Muñoz, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707168/ https://www.ncbi.nlm.nih.gov/pubmed/23697951 http://dx.doi.org/10.3390/md11051677

Ejemplares similares

Plitidepsin: design, development, and potential place in therapy
por: Alonso-Álvarez, Sara, et al.
Publicado: (2017)

Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment
por: Galmarini, Carlos M., et al.
Publicado: (2014)

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin
por: Losada, Alejandro, et al.
Publicado: (2016)

Plitidepsin for multiple myeloma
Publicado: (2019)

Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis
por: Sachse, Martin, et al.
Publicado: (2022)

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts
por: Delgado-Calle, Jesus, et al.
Publicado: (2019)

c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies
por: Rzeczkowski, Katharina, et al.
Publicado: (2011)

Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
por: Varona, Jose F, et al.
Publicado: (2022)

Plitidepsin: a Repurposed Drug for the Treatment of COVID-19
por: Martinez, Miguel Angel
Publicado: (2021)

c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1
por: Tian, Xiaodong, et al.
Publicado: (2021)

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
por: Khalid, Sana, et al.
Publicado: (2016)

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
por: Biggi, Silvia, et al.
Publicado: (2017)

C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy
por: Klein, SR, et al.
Publicado: (2015)

Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis
por: Takaki, Hiroko, et al.
Publicado: (2017)

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases
por: Guma, Monica, et al.
Publicado: (2012)

Jun N-terminal kinase signaling makes a face
por: Hursh, Deborah A., et al.
Publicado: (2016)

Plitidepsin in adult patients with COVID-19 requiring hospital admission: A long-term follow-up analysis
por: Varona, Jose F., et al.
Publicado: (2023)

Phase I study of plitidepsin in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma
por: Mateos, María Victoria, et al.
Publicado: (2022)

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
por: White, Kris M., et al.
Publicado: (2021)

c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea123
por: Anttonen, Tommi, et al.
Publicado: (2016)

Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH(2)-terminal kinase–interacting protein-1
por: Muresan, Zoia, et al.
Publicado: (2005)

c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks
por: Barkley, Laura R., et al.
Publicado: (2012)

Increased phosphorylation of c-Jun NH (2)-terminal protein kinase in the sciatic nerves of Lewis rats with experimental autoimmune neuritis
por: Ahn, Meejung, et al.
Publicado: (2006)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
por: Duong, Men Thi Hoai, et al.
Publicado: (2020)

C‐Jun N‐terminal kinase signalling pathway in response to cisplatin
por: Yan, Dong, et al.
Publicado: (2016)

Inhibitors of c-Jun N-terminal kinases—JuNK no more?
por: Bogoyevitch, Marie A., et al.
Publicado: (2008)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

c-Jun N-Terminal Kinase Signaling Inhibitors Under Development
por: Han, Sun-Young
Publicado: (2008)

Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
por: Noguchi, Hirofumi
Publicado: (2019)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

Plitidepsin Has a Safe Cardiac Profile: A Comprehensive Analysis
por: Soto-Matos, Arturo, et al.
Publicado: (2011)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury
por: Shvedova, Maria, et al.
Publicado: (2018)

On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
por: Rossato, Janine I., et al.
Publicado: (2022)

c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas
por: Heiland, Dieter H, et al.
Publicado: (2016)

Profiling Transcriptional Regulation and Functional Roles of Schistosoma mansoni c-Jun N-Terminal Kinase
por: Gava, Sandra Grossi, et al.
Publicado: (2019)

Phosphorylation of purified mitochondrial Voltage-Dependent Anion Channel by c-Jun N-terminal Kinase-3 modifies channel voltage-dependence
por: Gupta, Rajeev, et al.
Publicado: (2017)

Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation
por: Jeong, Myoung Seok, et al.
Publicado: (2019)

Krox-20 inhibits Jun-NH(2)-terminal kinase/c-Jun to control Schwann cell proliferation and death
por: Parkinson, David B., et al.
Publicado: (2004)

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
por: Yarza, Ramon, et al.
Publicado: (2016)

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
por: Palumbo, Camilla, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_btivtq7j151ahk21sl6o3t18av