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Antimicrobial Resistance Mechanisms among Campylobacter

Campylobacter jejuni and Campylobacter coli are recognized as the most common causative agents of bacterial gastroenteritis in the world. Humans most often become infected by ingesting contaminated food, especially undercooked chicken, but also other sources of bacteria have been described. Campylob...

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Autores principales: Wieczorek, Kinga, Osek, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707206/
https://www.ncbi.nlm.nih.gov/pubmed/23865047
http://dx.doi.org/10.1155/2013/340605
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author Wieczorek, Kinga
Osek, Jacek
author_facet Wieczorek, Kinga
Osek, Jacek
author_sort Wieczorek, Kinga
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description Campylobacter jejuni and Campylobacter coli are recognized as the most common causative agents of bacterial gastroenteritis in the world. Humans most often become infected by ingesting contaminated food, especially undercooked chicken, but also other sources of bacteria have been described. Campylobacteriosis is normally a self-limiting disease. Antimicrobial treatment is needed only in patients with more severe disease and in those who are immunologically compromised. The most common antimicrobial agents used in the treatment of Campylobacter infections are macrolides, such as erythromycin, and fluoroquinolones, such as ciprofloxacin. Tetracyclines have been suggested as an alternative choice in the treatment of clinical campylobacteriosis but in practice are not often used. However, during the past few decades an increasing number of resistant Campylobacter isolates have developed resistance to fluoroquinolones and other antimicrobials such as macrolides, aminoglycosides, and beta-lactams. Trends in antimicrobial resistance have shown a clear correlation between use of antibiotics in the veterinary medicine and animal production and resistant isolates of Campylobacter in humans. In this review, the patterns of emerging resistance to the antimicrobial agents useful in treatment of the disease are presented and the mechanisms of resistance to these drugs in Campylobacter are discussed.
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spelling pubmed-37072062013-07-17 Antimicrobial Resistance Mechanisms among Campylobacter Wieczorek, Kinga Osek, Jacek Biomed Res Int Review Article Campylobacter jejuni and Campylobacter coli are recognized as the most common causative agents of bacterial gastroenteritis in the world. Humans most often become infected by ingesting contaminated food, especially undercooked chicken, but also other sources of bacteria have been described. Campylobacteriosis is normally a self-limiting disease. Antimicrobial treatment is needed only in patients with more severe disease and in those who are immunologically compromised. The most common antimicrobial agents used in the treatment of Campylobacter infections are macrolides, such as erythromycin, and fluoroquinolones, such as ciprofloxacin. Tetracyclines have been suggested as an alternative choice in the treatment of clinical campylobacteriosis but in practice are not often used. However, during the past few decades an increasing number of resistant Campylobacter isolates have developed resistance to fluoroquinolones and other antimicrobials such as macrolides, aminoglycosides, and beta-lactams. Trends in antimicrobial resistance have shown a clear correlation between use of antibiotics in the veterinary medicine and animal production and resistant isolates of Campylobacter in humans. In this review, the patterns of emerging resistance to the antimicrobial agents useful in treatment of the disease are presented and the mechanisms of resistance to these drugs in Campylobacter are discussed. Hindawi Publishing Corporation 2013 2013-06-24 /pmc/articles/PMC3707206/ /pubmed/23865047 http://dx.doi.org/10.1155/2013/340605 Text en Copyright © 2013 K. Wieczorek and J. Osek. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wieczorek, Kinga
Osek, Jacek
Antimicrobial Resistance Mechanisms among Campylobacter
title Antimicrobial Resistance Mechanisms among Campylobacter
title_full Antimicrobial Resistance Mechanisms among Campylobacter
title_fullStr Antimicrobial Resistance Mechanisms among Campylobacter
title_full_unstemmed Antimicrobial Resistance Mechanisms among Campylobacter
title_short Antimicrobial Resistance Mechanisms among Campylobacter
title_sort antimicrobial resistance mechanisms among campylobacter
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707206/
https://www.ncbi.nlm.nih.gov/pubmed/23865047
http://dx.doi.org/10.1155/2013/340605
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